TrkB antibody (20R-TR014)

Rabbit polyclonal TrkB antibody

Synonyms Polyclonal TrkB antibody, Anti-TrkB antibody, Trk-B antibody, Trk B antibody
Specificity Rat
Cross Reactivity Mouse
Applications WB
Immunogen TrkB antibody was raised in rabbit using the entire extracellular domain of rat TrkB receptor as the immunogen.

Images

Western blot analysis using TrkB antibody (20R-TR014)

Western blot analysis of Mouse brain membrane protein preparation probed with anti-TrkB (1 microgram/ml).

Specifications

Host Rabbit
Isotype IgG
Method of Purification TrkB antibody was purified by Protein A chromatography.
Molecular Weight 145 kDa (predicted detection band MW)
Form & Buffer 0.014M PO4 buffer, pH 7.6, with 0.175 M NaCl, 0.07% NaN3, and 30% glycerol.
Concentration Batch dependent - please inquire should you have specific requirements

Usage & Assay Information

Usage Recommendations Optimal conditions to be determined by end user

Storage & Safety

Storage Aliquot and store at -20 deg C. Avoid repeated Freeze/Thaw cycles
Biohazard Information This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling.

General Information

Biological Significance The Trk (tropomyosin-receptor-kinase) proto-oncogene family of receptor tyrosine kinases contains four members, TrkA, Tr kb, TrkC, and TrkE, which are variably expressed throughout the central and peripheral nervous systems. Tr kb is the high-affinity to the binding brain-derived neurotrophic factor (BDNF) receptor and neurotrophin-4/5 NT-4/5). The binding of BDNF to Tr kb receptor causes many intercellular cascades to be activated such as promoting survival of sensory neurons mainly through Shc site-independent pathways.

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Images

  • Western blot analysis using TrkB antibody (20R-TR014) | Western blot analysis of Mouse brain membrane protein preparation probed with anti-TrkB (1 microgram/ml).

Availability: In stock

Price: $535.00
Size: 200 ug
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