Troponin I protein (Cardiac) (30-AT43)

Purified native Human Troponin I protein (Cardiac)

Species Human
Protein Type Native
Applications User optimized

Specifications

Source Human cardiac tissue
Purity > 99% pure
Method of Purification Purified by ion-exchange and Tn-C affinity chromatography
Form & Buffer Supplied as a liquid in 8M Urea, 0.05M Tris HCl, 0.015M beta-mercaptoethanol, 2mM EDTA, pH 7.4

Storage & Safety

Storage Store at -20 degC to -70 deg C, avoid repeated freeze/thaw cycles
Biohazard Information Donor samples were tested and found to be negative for HBsAg, Anti-HIV-1/HIV-2, & HCV. Nonetheless caution should be used when handling this material as there is a margin of error in all tests.

General Information

Biological Significance Troponin I is a part of the troponin complex. It binds to actin in thin myofilaments to hold the actin-tropomyosin complex in place. Because of it myosin cannot bind actin in relaxed muscle. When calcium binds to the Troponin C it causes conformational changes which lead to dislocation of troponin I and finally tropomyosin leaves the binding site for myosin on actin leading to contraction of muscle. The letter I is given due to its inhibitory character.

References
Add a Paper

S.P. Mulvaney, C.L. Cole, M.D. Kniller, M. Malito, C.R. Tamanaha, J.C. Rife, M.W. Stanton, L.J. Whitman

Rapid, femtomolar bioassays in complex matrices combining microfluidics and magnetoelectronics

Biosensors and Bioelectronics

Volume: 23 Issue: 2 Page: 191-200 DOI: 10.1016/j.bios.2007.03.029

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Availability: In stock

Price: $614.25
Size: 100 ug
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