Troponin I protein (Skeletal Muscle) (30R-AT060)

Purified native Troponin I protein (Skeletal Muscle)


Source Human Skeletal Muscle
Purity > 95% pure
Form & Buffer Lyophilized in 0.01M HCl. Reconstitute in Urea/Tris buffer: 0.02 M Tris, 7 M Urea, 5 mM EDTA and 15m M mercaptoethanol, pH 7.5. Solubility is limited at neutral pH and Physiological salt concentration
Concentration 100 ug per vial

Storage & Safety

Storage Store at -20 deg C
Biohazard Information Tissue Donor was tested and found negative for HBsAg, HIV-1 and HIV-2 antibodies, HCV and Syphilis.

General Information

Biological Significance Troponin I is a part of the troponin complex. It binds to actin in thin myofilaments to hold the actin-tropomyosin complex in place. Because of it myosin cannot bind actin in relaxed muscle. When calcium binds to the Troponin C it causes conformational changes which lead to dislocation of troponin I and finally tropomyosin leaves the binding site for myosin on actin leading to contraction of muscle. The letter I is given due to its inhibitory character.

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Availability: In stock

Price: $295.00
Size: 100 ug
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