TSH beta antibody (10-T25C)

Mouse monoclonal TSH beta antibody

Synonyms Monoclonal TSH beta antibody, Anti-TSH beta antibody, TSHB antibody, Thyrotropin beta subunit antibody, Thyrotropin beta subunit antibody, Thyrotropin beta chain precursor antibody, Thyrotropin beta chain precursor antibody, Thyroid stimulating hormone beta precursor antibody, TSH beta antibody, Thyroid stimulating hormone beta subunit antibody, Thyroid stimulating hormone beta subunit antibody, CHNG4 antibody, Anti TSH beta antibody, CHNG4 antibody, Thyroid stimulating hormone beta precursor antibody, TSHB antibody
Specificity Human
Cross Reactivity To be determined by end-user
Applications User optimized
Immunogen TSH beta antibody was raised in mouse using human TSH beta as the immunogen.
Assay Information Matched pair antibody available for TSH beta antibody: 10-T25B

Specifications

Host Mouse
Clone M94206
Isotype IgG
Purity > 95% pure
Method of Purification Chromatographically purified (S-200, DEAE) immunoglobulin fraction
Form & Buffer Chromatographically purified IgG fraction supplied in 50mM PBS buffer, pH 7.4 with 0.1% NaN3.
Concentration Batch dependent - please inquire should you have specific requirements

Storage & Safety

Storage Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Biohazard Information This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.

General Information

Biological Significance Thyroid stimulating hormone (TSH) is a peptide hormone synthesized and secreted by thyrotrope cells in the anterior pituitary gland, which regulates the endocrine function of the thyroid gland. TSH is a glycoprotein that consists of alpha and beta subunits. The ? subunit is thought to be the effector region responsible for stimulation of adenylate cyclase (involved the generation of cAMP). The ? (beta) subunit (TSHB) is unique to TSH, and therefore determines its receptor specificity.

References
Add a Paper

Hattori N, Ishihara T, Yamagami K, Shimatsu A

Macro TSH in patients with subclinical hypothyroidism

Clinical Endocrinology

PMID: 25388002 DOI: 10.1111/cen.12643

Hattori N, Ishihara T, Matsuoka N, Saito T, Shimatsu A

Anti-TSH autoantibodies in patients with macro-TSH and long-term changes in macro-TSH and serum TSH levels

Thyroid

PMID: 27785976 DOI: 10.1089/thy.2016.0442

Hattori N, Ishihara T, Shimatsu A.

Variability in the detection of macro TSH in different immunoassay systems

Eur J Endocrinol.

Volume: 1 (Jan 2015) Issue: 174 Page: 9-15 PMID: 26438715 DOI: 10.1530/EJE-15-0883

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TSH beta antibody

Mouse monoclonal TSH beta antibody

Availability: In stock

Price: $137.50
Size: 1 mg
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