TTC11 protein (His tag) (80R-1326)
Purified recombinant Human TTC11 protein
|Synonyms||FIS1 protein, FIS 1 protein, hFis1 protein, TTC11, TTC-11, CGI135 protein, TTC 11, homolog of protein, Fission 1 (mitochondrial outer membrane) homolog (S protein, Tetratricopeptide repeat protein 11 protein, cerevisiae) protein, Mitochondrial fission 1 protein protein, TPR repeat protein 11 protein, cerevisiae protein, TTC 11., Fis1 homolog protein, Fission 1 (mitochondrial outer membrane) homolog protein, CGI 135 protein, S protein, Fission 1 (mitochondrial outer membrane) homolog (yeast) Fission 1 homolog protein, H NH0132A01.6 protein, hFis 1 protein, TTC-11 protein, FIS1 protein, Tetratricopeptide repeat domain 11 2010003O14Rik protein, TTC 11 protein|
Coomassie Blue stained SDS-PAGE of TTC11 protein (His tag) (80R-1326)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-122 amino acids: MGSSHHHHHH SSGLVPRGSH MEAVLNELVS VEDLLKFEKK FQSEKAAGSV SKSTQFEYAW CLVRSKYNDD IRKGIVLLEE LLPKGSKEEQ RDYVFYLAVG NYRLKEYEKA LKYVRGLLQT EPQNNQAKEL ERLIDKAMKK DG|
|Purity||> 95% pure|
|Molecular Weight||16.3 kDa(142aa), confirmed by MALDI-TOF|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl Buffer, pH 8.0, containing 10% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||TTC11 is a component of a mitochondrial complex that promotes mitochondrial fission. This protein can induce cytochrome C release from the mitochondrion to the cytosol, ultimately leading to apoptosis. It is also involved in peroxisomal growth and division. The C terminus is required for mitochondrial localisation, while the N teminus is necessary for mitochondrial fission. Recombinant human TTC11, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.|
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