tTG protein (His tag) (80-1379)

Purified recombinant tTG protein (His tag)

Synonyms Tissue transglutaminase protein, TGM2 protein, G-ALPHA-h protein, GNAH protein, TG2 protein, TG protein
Species Human
Protein Type Recombinant

Images

Western Blot analysis using tTG protein (His tag) (80-1379)

Specifications

Residues 1-687 aa
Expression System E.coli
Purity > 85% pure
Method of Purification Purified using proprietary chromatographic techniques
Molecular Weight 77 kDa
Tag/Conjugate His tag
Form & Buffer Supplied in 50mM Tris buffer pH 7.5, 150mM NaCl, 10% glycerol, 1mM EDTA and 2mM DTT

Storage & Safety

Storage Store at 4 deg C for short term storage. Aliquot and store at -70 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance TTG crosslinks proteins between an e-amino group of a lysine residue and a ?-carboxamide group of glutamine residue, creating an inter- or intramolecular bond that is highly resistant to proteolysis (protein degradation).
Expression tTG is highly expressed in acute lymphoblastic T-cell leukemia. Tissue and Cell Localization: tTG is found in the nucleus of most mammalian cells, it is expressed mainly in the central nervous. Low level of expression in other tissues including thymus.
Implications in Disease A chromosomal aberration involving tTG may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Defects in tTG expression have also been associated with cd3epsilon deficiency and Celiac Disease, an autoimmune disorder of the small intestine that occurs in genetically predisposed people of all ages from middle infancy onward.
Post-Translational Modifications Does not undergo any major post-translational modifications.
Database Links Entrez Gene: 7052 Human, Omim: 190196 Human, SwissProt: P21980 Human, Unigene: 517033 Human

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Images

  • Western Blot analysis using tTG protein (His tag) (80-1379)

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