TTR antibody (10R-1176)

Mouse monoclonal TTR antibody

Synonyms Monoclonal TTR antibody, Anti-TTR antibody, Senile systemic amyloidosis antibody, Anti TTR antibody , ATTR antibody, TTR antibody, Senile systemic amyloidosis antibody, TBPA antibody, Dysprealbuminemic euthyroidal hyperthyroxinemia antibody, TTR antibody, ATTR antibody, Transthyretin antibody, Amyloidosis I antibody, HsT2651 antibody, PALB antibody, Dystransthyretinemic hyperthyroxinemia antibody, Prealbumin amyloidosis type I antibody, Prealbumin amyloidosis type I antibody, TTR protein. antibody, Amyloidosis I antibody, Transthyretin antibody, Dystransthyretinemic hyperthyroxinemia antibody, TTR protein. antibody, Amyloid polyneuropathy antibody, PALB antibody, TTR antibody, Amyloid polyneuropathy antibody, Dysprealbuminemic euthyroidal hyperthyroxinemia antibody, TBPA antibody, HsT2651 antibody
Specificity Human
Cross Reactivity Human, Mouse
Applications ELISA, WB
Immunogen TTR antibody was raised in mouse using recombinant human TTR (21-147aa) purified from E.coli (corresponding to 30R-1456) as the immunogen.

Images

Western Blot analysis of TTR antibody (10R-1176)

Mouse Liver lysates (35 ug) were resolved by SDS-PAGE, transferred to nitrocellulose membrane and probed with anti-human TTR (1:3000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.

Specifications

Host Mouse
Clone AT7B2
Isotype IgG1 kappa
Source Anti-human TTR antibody, clone AT7B2, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human TTR protein.
Method of Purification TTR antibody was purified by protein-G affinity chromatography
Form & Buffer Supplied as a liquid in PBS, pH 7.4, with 0.1% NaN3.
Concentration 1 mg/ml

Usage & Assay Information

Usage Recommendations WB: 1:500-1:3,000

Storage & Safety

Storage Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance TTR encodes transthyretin, a circulating and abundant tetramer that functions as a carrier protein of thyroid hormone and retinol binding protein. Transthyretin(TTR) is mainly produced in the liver, but also in the brain and eye. Mutations in TTR cause the protein to dissociate into monomers that after misfolding assemble into amyloid fibrils deposits in a diversity of organs. TTR is also the only gene known to be associated with familial TTR amyloidosis. Familial transthyretin (TTR) amyloidosis is characterized by a slowly progressive peripheral sensorimotor neuropathy and autonomic neuropathy as well as non-neuropathic changes of cardiomyopathy, nephropathy, vitreous opacities, and CNS amyloidosis.

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Images

  • Western Blot analysis of TTR antibody (10R-1176) | Mouse Liver lysates (35 ug) were resolved by SDS-PAGE, transferred to nitrocellulose membrane and probed with anti-human TTR (1:3000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.

Availability: In stock

Price: $295.00
Size: 100 ul
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