UBE2M protein (His tag) (80R-2343)
Purified recombinant Human UBE2M Protein (His tag)
|Synonyms||UBEM 2, UBE2M, NEDD8-conjugating enzyme Ubc12 protein, UBC12 protein, UBEM 2 protein, UBEM-2, UBC-RS2 protein, hUbc12 protein, UBEM-2 protein|
Coomassie Blue stained SDS-PAGE of UBE2M protein (His tag) (80R-2343)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||MGSSHHHHHH SSGLVPRGSH MGSHMIKLFS LKQQKKEEES AGGTKGSSKK ASAAQLRIQK DINELNLPKT CDISFSDPDD LLNFKLVICP DEGFYKSGKF VFSFKVGQGY PHDPPKVKCE TMVYHPNIDL EGNVCLNILR EDWKPVLTIN SIIYGLQYLF LEPNPEDPLN KEAAEVLQNN RRLFEQNVQR SMRGGYIGST YFERCLK|
|Purity||> 95% pure|
|Molecular Weight||23.5 kDa|
|Form & Buffer||Supplied in liquid form in 20mM Tris-HCl buffer (pH 8.0) containing 20% glycerol, 0.2M NaCl, 1mM DTT|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1-2 weeks). Aliquot and store at -20 deg C to -70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||UBE2M, also known as NEDD8-conjugating enzyme Ubc12, belongs to the ubiquitin-conjugating enzyme family. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is linked with a ubiquitin-like protein, NEDD8, which can be conjugated to cellular proteins, such as Cdc53/culin. Recombinant human UBE2M protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.|
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