UBE2N protein (His tag) (80R-1751)
Purified recombinant Human UBE2N protein
|Synonyms||UbcH-ben protein, UBEN-2 protein, UBEN 2 protein, MGC131857 protein, UBEN 2, UBC13 protein, MGC8489 protein, UBEN-2, Ubiquitin-conjugating enzyme E2 N protein, UBE2N|
Coomassie Blue stained SDS-PAGE of UBE2N protein (His tag) (80R-1751)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-152 amino acids: MGSSHHHHHH SSGLVPRGSH MAGLPRRIIK ETQRLLAEPV PGIKAEPDES NARYFHVVIA GPQDSPFEGG TFKLELFLPE EYPMAAPKVR FMTKIYHPNV DKLGRICLDI LKDKWSPALQ IRTVLLSIQA LLSAPNPDDP LANDVAEQWK TNEAQAIETA RAWTRLYAMN NI|
|Purity||> 95% pure|
|Molecular Weight||19.3 kDa(172aa), confirmed by MALDI-TOF|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 20% glycerol, 0.1M NaCl and 1mM DTT.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||UBE2N, also known as UBC13, is a member of the E2 ubiquitin-conjugating enzyme family. It catalyzes the ATP-dependent synthesis of non-canonical polyubiquitin chains, a process that does not lead to proteasomal degradation. It mediates the transcription of several target genes and is thought to play a role in cell cycle progression; cellular differentiation and DNA repair mechanisms that ensure cell survival after DNA damage. Recombinant human UBE2N protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.|
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