Ubiquitin+1 antibody (20R-2971)

Rabbit polyclonal Ubiquitin+1 antibody

Synonyms Polyclonal Ubiquitin+1 antibody, Anti-Ubiquitin+1 antibody, UBA52 antibody, ubiquitin A-52 residue ribosomal protein fusion product 1 antibody, 60S ribosomal protein L40 antibody, B9 antibody, BOS_7110 antibody, CEP52 antibody, D8Ertd21e antibody, hubcep52 antibody, L40 antibody, rpl40 antibody, Rps27a antibody, TNeu060o20.1 antibody, Ubb antibody, Ubc antibody, UBCEP2 antibody, ubiquitin-52 amino acid fusion protein antibody, ubiquitin/60S ribosomal fusion protein antibody, ubiquitin-60S ribosomal protein L40 antibody, ubiquitin and ribosomal protein L40 antibody, ubiquitin carboxyl extension protein 52 antibody, ubiquitin-CEP52 antibody, ubiquitin/ribosomal fusion protein antibody, ubiquitin-ribosomal protein fusion protein antibody, UB-RPL40 antibody
Cross Reactivity Human
Applications IP, WB
Immunogen Ubiquitin+1 antibody was raised in Rabbit using a synthetic target peptide as the immunogen

Images

Western Blot analysis using Ubiquitin+1 antibody (20R-2971)

Specifications

Host Rabbit
Isotype IgG
Method of Purification Ubiquitin+1 antibody was purified by Protein A affinity chromatography
Form & Buffer Supplied in liquid form in HEPES buffer with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol

Usage & Assay Information

Usage Recommendations WB: 1:5000, IP: 5 ul

Storage & Safety

Storage Aliquot and store for 1 year at -20 deg C, avoid freeze/thaw cycles

General Information

Biological Significance Ubiquitin+1 (Ub+1) is a novel mutant form of ubiquitin that can be produced through a process known as molecular frame shift. Ub+1 can be polyubiquitinated to produce aberrant polyubiquitin chains that inhibit the 26S proteasome. Especially ub+1 is accumulated in aggregates containing amyloid-beta and phosphorylated-tau. Elevated expression of Ub+1 mRNA and protein has been observed in the brains of patients with Alzheimer's disease. Also Ub+1 acts as an aggravating factor in polyglutamine-induced neurodegeneration.

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Images

  • Western Blot analysis using Ubiquitin+1 antibody (20R-2971) |

Availability: In stock

Price: $295.00
Size: 100 ul
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