Ubiquitin+1 protein (30R-3010)

Purified recombinant Ubiquitin+1 protein

Synonyms ubi protein, ub protein, ub+1 protein, ub +1 protein, ubiquitin b protein, Ubiquitin protein, FLJ25987 protein, MGC8385 protein, Polyubiquitin B protein, RPS27A protein, UBA52 protein, UBA80 protein, UBB protein, UBC protein, UBCEP1 protein, UBCEP2 protein, Ubiquitin protein, Ubiquitin B protein
Species Human
Protein Type Recombinant
Applications WB

Images

Western Blot analysis using Ubiquitin+1 protein (30R-3010)

Specifications

Expression System E.coli
Purity > 95% pure
Molecular Weight 37 kDa
Form & Buffer Supplied in liquid form in 20mM HEPES, pH7.0, 10% Glycerol
Concentration 1mg/ml

Storage & Safety

Storage Store at -80 deg C. Avoid frequent freeze/thaw cycles

General Information

Biological Significance Ubiquitin+1 (Ub+1) is a novel mutant form of ubiquitin that can be produced through a process known as molecular frameshift. Ub+1 can be polyubiquitinated to produce aberrant polyubiquitin chains that inhibit the 26S proteasome. Especially ub+1 is accumulated in aggregates containing amyloid-beta and phosphorylated-tau. Elevated expression of Ub+1 mRNA and protein has been observed in the brains of patients with Alzheimer's disease. Also ub+1 acts as an aggravating factor in polyglutamine-induced neuro-degeneration.

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Images

  • Western Blot analysis using Ubiquitin+1 protein (30R-3010) |

Availability: In stock

Price: $175.00
Size: 500 ug
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