UCHL3 antibody (10R-8592)

Mouse monoclonal UCHL3 antibody

Synonyms Monoclonal UCHL3 antibody, Anti-UCHL3 antibody, UCHL3 antibody, ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) antibody, BOS_12557 antibody, DKEY-57A22.6 antibody, rCG_37146 antibody, RGD1561196 antibody, RP11-173B14.3 antibody, ubiquitin carboxyl-terminal esterase L4 antibody, ubiquitin carboxyl-terminal hydrolase-6 antibody, ubiquitin carboxyl-terminal hydrolase isozyme L3 antibody, ubiquitin thioesterase L3 antibody, ubiquitin thiolesterase antibody, UCH-6 antibody, UCH-L3 antibody, uchl4 antibody
Cross Reactivity Human, Mouse, Rat
Applications ELISA, WB
Immunogen UCHL3 antibody was raised in Mouse using a recombinant human protein purified from E.coli (GST-UCHL3) as the immunogen

Images

Western Blot analysis using UCHL3 antibody (10R-8592)

Specifications

Host Mouse
Clone AF9G8
Isotype IgG2b kappa
Method of Purification UCHL3 antibody was purified by ammonium sulfate precipitation
Form & Buffer Supplied in liquid form in HEPES buffer with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol

Usage & Assay Information

Usage Recommendations WB: 1:2000

Storage & Safety

Storage Aliquot and store for 1 year at -20 deg C, avoid freeze/thaw cycles

General Information

Biological Significance UCHL3 is universally expressed in all tissues, while UCHL1 is expressed exclusively in neuronal tissue, testis and ovary. The activity of UCHL3 is more than 200 fold higher than UCHL1 when a fluorogenic ubiquitin substrate is used. UCHL1 associates with monoubiquitin and UCHL3 binds to Nedd8, ubiquitin-like protein. UCHL1 and UCHL3 play a role in the regulation of neuronal development and spermatogenesis. UCHL1 is involved in the pathogenesis of Parkinson?s disease (PD) and Alzheimer?s disease (AD). Down-regulation and extensive oxidative modification of UCHL1 have been observed in the brains of AD patients as well as PD patients.

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Images

  • Western Blot analysis using UCHL3 antibody (10R-8592) |

Availability: In stock

Price: $295.00
Size: 100 ul
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