UPK3A protein (His tag) (80R-2046)

Recombinant human UPK3A protein (His tag)

Synonyms UPK3 protein, UPKA 3, UPK3A, Uroplakin-3a protein, UPKA-3 protein, UPKA-3, UPKA 3 protein
Species Human
Protein Type Recombinant
Applications SDS-PAGE

Images

SDS-PAGE analysis of UPK3A protein (His tag) (80R-2046)

SDS-PAGE gel analysis of UPK3A protein (His tag) where the figure is annotated with amount of protein run on the gel.

Specifications

Residues 19-207 amino acids: MGSSHHHHHH SSGLVPRGSH MGSHMVNLQP QLASVTFATN NPTLTTVALE KPLCMFDSKE ALTGTHEVYL YVLVDSAISR NASVQDSTNT PLGSTFLQTE GGRTGPYKAV AFDLIPCSDL PSLDAIGDVS KASQILNAYL VRVGANGTCL WDPNFQGLCN PPLSAATEYR FKYVLVNMST GLVEDQTLWS DPIRTNQLTP YSTIDTWPGR RSGG
Expression System E.coli
Purity > 90% pure
Molecular Weight 23.1 kDa (214aa), confirmed by MALDI-TOF
Tag/Conjugate His tag
Form & Buffer Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 2mM DTT, 20% glycerol, 150mM NaCl
Concentration 0.25 mg/ml

Usage & Assay Information

Usage Recommendations UPK3A protein (His tag) has been used in SDS-PAGE, and may be suitable for use in other applications, to be determined by the end user.

Storage & Safety

Storage Can be stored at 4 deg C short term (1-2 weeks). For long term storage, aliquot and store at -20 deg C or -70 deg C. Avoid repeated freezing and thawing cycles.

General Information

Biological Significance UPK3A belongs to the uroplakin-3 family. Uroplakins (UP) are key components of the urothelium. They are transmembrane proteins that pass the lipid bilayer once (UPII, UPIIIa, and UPIIIb) or four times (UPIa and UPIb; both belonging to the "tetraspanin" family). All have large luminal/extracellular domains, but only UPIIIa and UPIIIb have significant cytoplasmic portions in their C-termini. UPK3A is a highly specific and moderately sensitive immunohistochemical marker for primary and metastatic urothelial carcinomas. Mutations in this gene may be associated with renal adysplasia Recombinant human UPK3A protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by conventional chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer.

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Images

  • SDS-PAGE analysis of UPK3A protein (His tag) (80R-2046) | SDS-PAGE gel analysis of UPK3A protein (His tag) where the figure is annotated with amount of protein run on the gel.

Availability: In stock

Price: $365.00
Size: 50 ug
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