Versican antibody (70R-14292)

Affinity purified Rabbit polyclonal Versican antibody

Synonyms Polyclonal Versican antibody, Anti-Versican antibody, CSPG2 antibody, VCAN antibody
Applications IHC-P, WB
Immunogen Versican antibody was raised in Rabbit using a synthetic peptide corresponding to a sequence at the C-terminal of human versican, identical to the related rat and Rabbit sequences, as the immunogen

Images

Immunohistochemical staining using Versican antibody (70R-14292)

Immunohistochemistry of paraffin-embedded section of Human Intestinal Cancer Tissue

Specifications

Host Rabbit
Isotype IgG
Method of Purification Versican antibody was purified by affinity chromatography
Form & Buffer Supplied in lyophilized form

Usage & Assay Information

Usage Recommendations Optimal conditions to be determined by the end user

Storage & Safety

Storage Store at 4 deg C for short term storage. For long term storage aliquot and store at -20 deg C, avoid repeated freeze/thaw cycles.

General Information

Biological Significance Versican is a large extracellular matrix proteoglycan that is present in a variety of human tissues. Versican is a large chondroitin sulfate proteoglycan with an apparent molecular mass of more than 1000 kDa.The Versican gene is mapped on 5q14.2-q14.3. The human versican gene contains 15 exons spanning more than 90 kb. The distribution of versican by using affinity-purified polyclonal antibodies that recognize the core protein of the prominent versican splice variants V0 and V1. Versican staining was noted in the central and peripheral nervous system, in the basal layer of the epidermis, and on the luminal surface of some glandular epithelia. Biochemical purification of LLC-conditioned medium led to identification of the extracellular matrix proteoglycan versican, which is upregulated in many human tumors including lung cancer, as a macrophage activator that acts through TLR2 and its coreceptors TLR6 and CD14. By activating TLR2:TLR6 complexes and inducing TNF-alpha secretion by myeloid cells, versican strongly enhances LLC metastatic growth.

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Images

  • <div><font face=Calibri size=2>Immunohistochemical staining using Versican antibody (70R-14292)</font></div>     | Immunohistochemistry of paraffin-embedded section of Human Intestinal Cancer Tissue
  • <div><font face=Calibri size=2>Western Blot analysis using Versican antibody (70R-14292)</font></div>     | Lane 1:Human Placenta Tissue Lysate; Lane 2:Rat Heart Tissue Lysate

Availability: In stock

Price: $270.00
Size: 100 ug
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