VHL antibody (10R-1029)

Mouse monoclonal VHL antibody

Synonyms Monoclonal VHL antibody, Anti-VHL antibody, RCA1 antibody, von Hippel Lindau syndrome antibody, von Hippel Lindau tumor suppressor antibody, Von Hippel-Lindau tumor suppressor isoform 1 pVHL antibody, von Hippel Lindau syndrome antibody, Von Hippel Lindau disease tumor suppressor antibody, G7 protein antibody, Von Hippel-Lindau tumor suppressor isoform 1 antibody, VHL 1 antibody, Elongin binding protein antibody, HRCA1 antibody, RCA 1 antibody, VHL antibody, RCA 1 antibody, HRCA 1 antibody, VHLH antibody, HRCA 1 antibody, Von Hippel-Lindau tumor suppressor isoform 1 pVHL antibody, G7 protein antibody, Von Hippel Lindau disease tumor suppressor antibody, Elongin binding protein antibody, VHL antibody, VHLH antibody, VHL1 antibody, RCA1 antibody, Von Hippel-Lindau tumor suppressor isoform 1 antibody, VHL antibody, HRCA1 antibody, Anti VHL antibody , VHL1 antibody, VHL 1 antibody, von Hippel Lindau tumor suppressor antibody
Specificity Human
Cross Reactivity To be determined by end-user.
Applications ELISA, WB
Immunogen VHL antibody was raised in mouse using recombinant human VHL (1-154aa) purified from E. coli as the immunogen.

Specifications

Host Mouse
Clone 52A11
Isotype IgG2b kappa
Source Anti-human VHL antibody, clone 52A11, is derived from hybridization of mouse SP2/O myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human VHL protein.
Method of Purification VHL antibody was purified by protein-G affinity chromatography
Form & Buffer Supplied as a liquid in PBS, pH 7.4, with 0.1% NaN3.
Concentration 1 mg/ml

Usage & Assay Information

Usage Recommendations WB: 1:500-1:1,000

Storage & Safety

Storage Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance Von Hippel-Lindau disease (VHL) is a dominant inherited syndrome characterized by the predisposition to develop various kinds of benign and malignant tumors, including clear cell renal carcinomas, pheochromocytomas and hemangioblastomas of the central nervous system and retina. VHL syndrome is caused by germline mutation in the VHL tumor suppressor, and VHL tumors are associated with loss or mutation of the remaining wild-type allele. VHL has two domains: a roughly 100-residue NH2-terminal domain rich in beta sheet and a smaller alpha-helical domain (alpha-domain), held together by two linkers and a polar interface. VHL protein is also involved in the degradation of hypoxia-inducible factor (HIF).

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Availability: In stock

Price: $265.00
Size: 100 ul
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