VISA antibody (70R-6462)

Rabbit polyclonal VISA antibody raised against the N terminal of VISA

Synonyms Polyclonal VISA antibody, Anti-VISA antibody, CARDIF antibody, IPS-1 antibody, Virus-Induced Signaling Adapter antibody, FLJ27482 antibody, DKFZp666M015 antibody, FLJ41962 antibody, MAVS antibody, KIAA1271 antibody
Specificity VISA antibody was raised against the N terminal of VISA
Cross Reactivity Human
Applications WB
Immunogen VISA antibody was raised using the N terminal of VISA corresponding to a region with amino acids ETQAPESPGENSEQALQTLSPRAIPRNPDGGPLESSSDLAALSPLTSSGH
Assay Information VISA Blocking Peptide, catalog no. 33R-2767, is also available for use as a blocking control in assays to test for specificity of this VISA antibody

Images

Western Blot analysis using VISA antibody (70R-6462)

VISA antibody (70R-6462) used at 1 ug/ml to detect target protein.

Specifications

Host Rabbit
Method of Purification Affinity purified
Molecular Weight 56 kDa (MW of target protein)
Form & Buffer Lyophilized powder. Add 50ul distilled water for a 1mg/ml concentration of VISA antibody in PBS
Concentration 1 mg/ml

Usage & Assay Information

Usage Recommendations WB: 1 ug/ml

Storage & Safety

Storage Store at 2-8 deg C for short periods. For longer periods of storage, store at -20 deg C. Avoid repeat freeze-thaw cycles.

General Information

Biological Significance Double-stranded RNA viruses are recognised in a cell type-dependent manner by the transmembrane receptor TLR3 or by the cytoplasmic RNA helicases MDA5 and RIGI (ROBO3). These interactions initiate signaling pathways that differ in their initial steps but converge in the activation of the protein kinases IKKA (CHUK) and IKKB (IKBKB), which activate NFKB, or TBK1 and IKKE (IKBKE), which activate IRF3. Activated IRF3 and NFKB induce transcription of IFNB (IFNB1). For the TLR3 pathway, the intermediary molecule before the pathways converge is the cytoplasmic protein TRIF (TICAM1). For RIGI, the intermediary protein is mitochondria-bound VISA.

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  • Western Blot analysis using VISA antibody (70R-6462) | VISA antibody (70R-6462) used at 1 ug/ml to detect target protein.

Availability: In stock

Price: $345.00
Size: 50 ug
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