XBP1 antibody (10R-1898)
Mouse monoclonal XBP1 antibody
|Synonyms||Monoclonal XBP1 antibody, Anti-XBP1 antibody, TREB5 antibody, XBP 1 antibody, XBP-1 antibody, XBP-1, Xbox binding protein 1 antibody, XBP 1, XBP1, XBP2 antibody|
|Immunogen||XBP1 antibody was raised in Mouse using a purified recombinant fragment of human XBP1 expressed in E. coli as the immunogen.|
Western Blot analysis using XBP1 antibody (10R-1898)
Western Blot showing XBP1 antibody used against XBP1 (AA: 1-160)-hIgGFc transfected HEK293 cell lysate.
|Form & Buffer||Supplied as a liquid in ascitic fluid containing 0.03% sodium azide.|
Usage & Assay Information
|Usage Recommendations||ELISA: 1:10,000, WB: 1:500-1:2000|
Storage & Safety
|Storage||Store at 4 deg C for short term storage. Store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1).|
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