YBX1 antibody (70R-14295)

Affinity purified Rabbit polyclonal YBX1 antibody

Synonyms Polyclonal YBX1 antibody, Anti-YBX1 antibody, YBX-1 antibody, Y box binding protein 1 antibody, YBX1, YBX 1 antibody, YBX-1, YBX 1, YB-1 antibody, YB1 antibody
Applications WB
Immunogen YBX1 antibody was raised in Rabbit using a synthetic peptide corresponding to a sequence in the middle region of human YBX1, identical to the related rat and Rabbit sequences, as the immunogen

Specifications

Host Rabbit
Isotype IgG
Method of Purification YBX1 antibody was purified by affinity chromatography
Form & Buffer Supplied in lyophilized form

Usage & Assay Information

Usage Recommendations Optimal conditions to be determined by the end user

Storage & Safety

Storage Store at 4 deg C for short term storage. For long term storage aliquot and store at -20 deg C, avoid repeated freeze/thaw cycles.

General Information

Biological Significance YB1 binding has an absolute requirement for the CCAAT box and relative specificity for the Y box. It has a molecular mass of 35,414 and contains 18% basic residues and putative nuclear localization signals. The YBX1 gene is mapped on 1p34.2. Ybx1 was highly expressed in mouse erythroid myeloid lymphoid clone-1 (EML), a hematopoietic precursor cell line, but that it was downregulated in myeloid progenitors and in Gmcsf-treated EML cells during myeloid differentiation. Ybx1 was expressed at high levels in myeloid leukemic cells at different developmental stages. Knockdown of YBX1 in a human leukemic cell line inhibited proliferation ability, induced apoptosis, and induced megakaryocytic differentiation in response to arsenic trioxide treatment. YBX1 is downregulated during myeloid differentiation and aberrant YBX1 expression in leukemic cells may contribute to leukemia development by blocking differentiation.

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Availability: In stock

Price: $270.00
Size: 100 ug
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